Quantitative effects of alpha-blockade

You will be presented with responses to adrenaline at various doses (1 nmole/kg), (3 nmole/kg), (10 nmole/kg), (30 nmole/kg) and (100 nmole/kg). For each dose measure the maximum increases in systolic blood pressure, decrease in diastolic blood pressure, the maximum increase in pulse pressure and the maximum increase in heart rate. Plot log₁₀ dose against size of response.

You will now be presented with responses to the same doses of adrenaline (1 nmole/kg), (3 nmole/kg), (10 nmole/kg), (30 nmole/kg) and (100 nmole/kg) but given after a dose of prazosin (200 nmole/kg). Note any changes in resting parameters produced by prazosin and repeat the required measurements on the responses to adrenaline. Plot the data on the same sheet of graph paper as previously.